Of mature blood cells, only chicken and rat thrombocytes express PCLP protein. Its expression decreases during differentiation of haematopoietic cells. In mice, PCLP is present in haemangioblasts, and in both chicken and mice it is a marker of early haematopoietic stem cells and lineage-restricted haematopoietic progenitors. It was first described in glomerular podocytes and endothelial cells. Podocalyxin-like protein (PCLP) is a sialomucin-type membrane protein structurally related to CD34 and endoglycan.
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